Antimicrobial Biomaterials

This project is at the centre of the Institute's push to develop ways of controlling bacterial infection by using a range of biomaterials.

Catheters used in hospitals have a relatively high rate of microbial colonisation, which results in a reduced life span when inserted into the body. Other biomaterials such as artificial heart values, prosthetic hips have a lower rate of microbial colonisation, but the consequences of this colonisation can be devastating, and must be treated by surgical removal and replacement.

The research will lead to a greater understanding of the mechanisms of action of certain antimicrobial materials. This project is investigating the effects of an antimicrobial agent call ‘melimine’ which has antibacterial effects on a wide range of bacteria. This knowledge can then be utilised in contact lens designs, providing greater protection against potential infection. We also examine potential antimicrobial biomaterials supplied by others for their in vitro and in vivo efficacy.

The research has application not only in the area of contact lenses, but more broadly in biomaterials such as those used in hospitals - catheters, artificial hearts and replacement joints.

Investigators

Project Leader
Dr Nerida Cole

Prof Mark Willcox
Ms Linda Garthwaite

PhD student
Riaz Rasul

Collaborators

The project involves collaborations with the School of Chemistry, University of New South Wales (Dr Naresh Kumar), and School of Chemistry, University of Sydney (Prof Robert Armstrong). This project also evaluates antimicrobial biomaterials on a contract basis for industrial clients.

Facilities

This project uses the extensive microbiology facilities at the Brien Holden Vision Institute as well as polymer chemistry and surface chemistry facilities at our collaborating institutes.