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CAPABILITIES

Our multidisciplinary research team includes experts in epidemiology, clinical research, biological sciences, technology development and optometry, ophthalmology and opticianary – all with relentless and insatiable passion for public health.

Clinical Research and Trial Services

Our Clinical Research and Trials Centre in Sydney is a specialised clinical research facility with capabilities and programs specifically designed to meet the needs of the ophthalmic and vision care industry.

Dedicated clinical research teams aim to identify and understand clinical problems by evaluating the performance of contemporary products.

We have the capacity, technical expertise and experience to generate effective product-based solutions.

Extensive laboratory facilities and the expertise of the scientific team provide a vital adjunct by enabling in-depth evaluation of the interaction between products and the ocular environment.

Activities

Clinical research activities are dedicated to developing and testing products for vision correction, including:
  • Contact lenses
  • Contact lens solutions
  • Spectacles
  • New instruments and techniques.
Clinical Research
Clinical Research
Cutting edge technology

With our technology team we have developed specialised instruments and software for our clinical research, including electronic vision charts for distance, intermediate and near testing and a customised clinical database.

We also possess cutting-edge commercial instruments, such as optical coherence tomography and laser interferometric biometry.


Standards and Guidelines

All optometrists are highly qualified, required to demonstrate concordance at regular intervals, and undergo regular training to maintain and enhance general and specialised optometric skills.

Local and international regulations and guidelines met include:
  • National Statement on Ethical Conduct in Human Research
  • Access to Unapproved Therapeutic Goods
  • Good Clinical Practice
  • Declaration of Helsinki.

Participant populations


In addition to our Sydney clinical trials centre, we have a clinical research facility at Brien Holden Vision Institute China in Guangzhou. We currently have more than 2,500 and 1,200 active participants listed on our Sydney and Guangzhou facilities respectively.

We also have access to overseas collaborators for trials that require special populations or a larger sample size.
Daniel TiliaClinical Research Manager
Dr Thomas NaduvilathInformation Sciences Manager
Jennie DiecSenior Research Optometrist
Dr Nisha YeotikarSenior Research Fellow
Belinda LudlowClinical Operations Manager

Technology - Novel Instruments and Know How

Contact lens metrology
  • Lens parameter measurements in accordance with ISO
  • Visualisation of optical zones and defects using unique Contact Lens Quality Analyser
  • Measuring the shape of soft contact lenses, including base curve profile
  • Assessment of contact lens optical performance for central and peripheral vision using life size model eye.

Developed and validated clinical assessment tools
  • Electronic Vision Charts for distance, intermediate and near
  • Testing of peripheral contrast sensitivity
  • Dynamic vision assessment, i.e. vision after blink
  • Peripheral refraction measurement

Material testing
  • Customised micro-tensometer to measure mechanical properties of contact lens materials under on-eye conditions
  • Determination of equivalent water content
  • Assessing surface wettability using meniscus height and meniscus force methods
  • Spectral transmission and refractive index measurements
  • Hydraulic conductivity of contact lens and related materials
Our novel instruments
  • Optical Quality Analyser (1985)
  • CRCERT-Belmonte Aesthesiometer (2000)
  • Ex Vivo Accommodation Simulator (2005)
  • Eye Tracker (2004)
  • Micro-Tensometer (2004)
  • Model Eye (2011)
  • EyeMapper (2011)
  • OCT Profilometer (2014)
  • Friction Meter (2015)

Improvements

  • Modified Autorefractor (2007)
  • Aberrometer (2009)
  • Measuring Microscope (2013)
Darrin FalkSenior Technical Officer
Indrani PereraResearch Scientist
Dr Klaus EhrmannDirector of Technology

TECHNOLOGY TRANSFER

In 2017, our extended depth of focus (EDOF) contact lens technology was licensed to SEED Co Ltd in Japan and mark’ennovy in Europe respectively, to produce contact lenses for myopia management as well as the correction of presbyopia.

A successful transfer of the licenced technology involves ongoing support from Brien Holden Vision Institute to ensure seamless integration of the licensed technology into existing manufacturing processes.

This process, managed by Science and Technology Manager, Dr Fabian Conrad, involves the areas of design creation, quality control, clinical validation and testing, as well as marketing and regulatory support.

QUALITY CONTROL SOFTWARE

We have developed patented software to aid quality control in the manufacturing of EDOF contact lenses. This involves a method for assessing the similarity between a power profile of a manufactured optic device and a nominal power profile upon which the power profile of the device is based. The software aids in ascertain the quality of the power profile confirms the optical power (label) of the manufactured lens.
Dr Fabian ConradScience and Technology Manager